Infant Health Publications

Infant Health


Year Authors Title Summary Reference
2021 McKeen S, Roy NC, Mullaney J, Eriksen H, Lovell A, Kussman M, Young W, Fraser K, Wall C, McNabb WC. Type of Milk Feeding and Introduction to Complementary Foods in Relation to Infant Sleep: A Systematic Review Review of existing literature on infant sleep and its relation to the timing of introduction to complementary foods and type of milk feeding to better understand their role(s) in infant sleep.  Exclusively breastfed infants (≤6 months-of-age) had a greater number of night wakings, but most studies (67%) reported no difference in night-time and 24 h sleep duration compared to formula-fed infants. However, after 6 months-of-age, most studies (>65%) reported breastfed infants to sleep less in the night-time and over 24 h compared to formula-fed infants. Studies reported no association between the timing of introduction to complementary foods and infant sleep duration (<12 months-of-age). 



2020 Heath A, Haszard J, Galland B, Lawley B, Rehrer N, Drummond L, Sims I, Taylor R, Otal A, Taylor B, and Tannock G. Association between the faecal short-chain fatty acid propionate and infant sleep An assessment of whether short-chain fatty acids (from indigestible plant sugars) are associated with longer uninterrupted sleep in infants. A higher proportion of total faecal short-chain fatty acids was associated with longer uninterrupted infant sleep.

European Journal of Clinical Nutrition 74: 1362


2020 McKeen S, Wall C, Eriksen H, Lovell A, Mullaney J, Young W, Fraser K, Roy N, McNabb W. Connecting Infant Complementary Feeding Patterns with Microbiome Development A look at the food groups that modulate the infant gut microbiome between 6 -12 months of age. Food intake data suggests that legumes, eggs, dairy, breastmilk and infant formula are most influential on microbial metabolic pathways.

Current Developments in Nutrition 4 (Suppl 2): 1034


2019 McKeen S, Young W, Mullaney J, Fraser K, McNabb W, and Roy N. Infant Complementary Feeding of Prebiotics for the Microbiome and Immunity A review of introducing complex, non-digestible carbohydrates to infants during the stage of complementary feeding, which promotes intestinal barrier integrity and immune development.

Nutrients 11(2): 364


2018 Michelini S, Balakrishnan B, Parolo S, Matone A, Mullaney J, Young W, Gasser O, Wall C, Priami C, Lombardo R, Kussmann M. A reverse metabolic approach to weaning: in silico identification of immune-beneficial infant gut bacteria, mining their metabolism for prebiotic feeds and sourcing these feeds in the natural product space Identification of an optimal weaning food for infant gut bacteria proliferation is determined by identifying the metabolite requirements of beneficial gut bacteria, determining the nutrients that contain these metabolites and, in turn, uncovering a potential ‘first food’ to boost the immune system of infants in the critical stage of complementary feeding.

Microbiome 6: 171