Metabolic Health Publications

Metabolic Health

 

Year Authors Title Summary Published
2020 Sequeira IR, Yip W, Lu LW, Jiang Y, Murphy R, Plank LD, Zhang S, Liu H, Chuang CL, Vazhoor-Amarsingh G, Cooper GJS, Poppitt SD. Visceral adiposity and key glucoregulatory peptides are associated with susceptibility to type 2 diabetes in an urban Chinese and Caucasian cohort: the TOFI-Asia Study. Study investigating adipose depots and clinical biomarkers as predictors of fasting plasma glucose and insulin resistance in lean and overweight normo- and dysglycemic Chinese and Caucasian individuals.  Visceral adipose tissue contributed to dysglycemia in both ethnicities, particularly in Chinese individuals characterised by the TOFI phenotype, as did glucoregulatory peptides amylin and C-peptide, providing targets for type 2 diabetes prevention.

Obesity

ARTICLE

2019 Mishra S, Monro J. Timing of fruit ingestion and blood glucose response (P12-014-19) This randomised cross-over design trial used preloading of a wheat-based breakfast cereal or kiwifruit in equicarbohydrate portions to determine the effect of kiwifruit on the glycaemic response. Consuming kiwifruit 30 minutes before the cereal reduced the blood glucose ‘spike’ significantly.

Current Developments in Nutrition 3(1)

ARTICLE

2019 Wu Z, Kruger M, Cooper JS, Poppitt SD, Fraser K. Tissue-specific sample dilution: an important parameter to optimise prior to untargeted LC-MS metabolomics A matrix to determine suitable injected concentrations when using untargeted LC-MS.

Metabolites 9(7): 124

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2018 Bermingham EN, Reis MG, Subbaraj AK, Cameron-Smith D, Fraser K, Jonker A, Craigie CR. Distribution of fatty acids and phospholipids in different table cuts and co-products from New Zealand pasture-fed Wagyu-dairy cross beef cattle Grass finished Wagyu-dairy cross beef has levels of omega-3 fatty acids and phospholipids to help meet dietary recommendations and play a role in cholesterol reduction. Co-products are richer in these nutrients than common table cuts.

Meat Science 140: 26-37

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2018 DeSouza SV, Singh RG, Yoon HD, Murphy R, Plank LD, Petrov MS. Pancreas volume in health and disease: a systematic review and meta-analysis Systematic review of  pancreas volume in both diseased and well states, using computer tomography and MRI. A larger pancreas is correlated to obesity; a smaller pancreas is consistent with Type 1 & 2 diabetes.

Expert Review Gastroenterology & Hepatology 12(8): 757-766

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2018 Fadason T, Schierding W, Lumley T, O’Sullivan JM. Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities A multimorbidity atlas of traits is constructed to help determine the influence of variants, SNPs and phenotypes involved in the pathogenesis of non-communicable diseases.

Nature Communications 9: 5198

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2018 Lu LW, Monro J, Lu J, Rush E. The effect of cold treatment of parboiled rice with lowered glycaemic potency on consumer liking and acceptability Cold treatment reduces the post-prandial blood glucose response. Cold treated, reheated, parboiled rice rates highest on consumer liking and acceptability among common rice consumers.

Foods 7(12): pii: E207

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2018 Lubransky A, Monro J, Mishra S, Yu H, Haszard J, Venn B. Postprandial Glycaemic, Hormonal and Satiety Responses to Rice and Kiwifruit Preloads in Chinese Adults: A Randomised Controlled Crossover Trial Splitting meals into two by preloading a rice meal with either rice itself or kiwifruit, demonstrated in this randomised cross-over trial that preloading of both kinds reduces postprandial glycaemia. When the meal was partially replaced by kiwifruit the insulin response was more effective also.

Nutrients 10(8): 1110

ARTICLE

2018 Monro J, Bentley-Hewitt K, Mishra S. Kiwifruit Exchanges for Increased Nutrient Richness with Little Effect on Carbohydrate Intake, Glycaemic Impact, or Insulin Response The nutrient density of kiwifruit enables it to be partially substituted for carbohydrate-rich foods without compromising on overall carbohydrate intake, glycaemic or insulin responses. This research compiled equi-carbohydrate substitution tables to aid dietary intervention.

Nutrients 10(11): 1710

ARTICLE

2018 Silvestre MP, McMahon C, Goode JP, Tay A, Poppitt SD. The role of glucagon in weight loss-mediated metabolic improvement: a systematic review and meta-analysis. A meta-analysis of glucagon suppression after weight loss with bariatric surgery or diet found that glucagon decreased in parallel with weight loss, irrespective of method.

Obesity Review 19(2): 233-253

ARTICLE

2017 Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice The published data-set for the below study about rutin and its suppression of human-amylin in transgenic mice.

Data in Brief 10: 298-303

ARTICLE

2017 Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice Human-amylin misfolds and aggregates causing β-cell apoptosis and diabetes progression. In human-amylin transgenic mice, the flavonol rutin suppressed aggregation in-vitro and mitigated the progression of diabetes in the mice.  

Biochemical and Biophysical Research Communications 482(4): 625-631

ARTICLE

2017 Fadason T, Ekblad C, Ingram JR, Schierding W, O’Sullivan JM. Physical interactions and expression quantitative traits loci identify regulatory connections for obesity and Type 2 Diabetes associated SNPs A genetic look at the relationship between obesity and type 2 diabetes pathogenesis via the impact of known SNPs on genes and function in tissue types.

Frontiers in Genetics 8: 150

ARTICLE

2017 Mishra S, Edwards H, Hedderley D, Podd J, Monro J. Kiwifruit non-sugar components reduce glycaemic response to co-ingested cereal in humans An RCT of the glycaemic response after consuming a wheat-based cereal with kiwifruit, guar gum and/or the sugar loading of kiwifruit (glucose). Hypoglycaemia only occurred in the glucose sample, suggesting non-sugar components of kiwifruit are responsible for the ameliorating effect on blood sugars.

Journal of Nutritional Science 9(11): 1195

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2017 Murphy R, Tsai P, Jüllig M, Liu A, Plank L, Booth M. Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission Roux-en-Y surgery yielded greater microbiota composition changes post surgery than sleeve gastrectomy. An equal number of randomised patients had Type 2 diabetes remission; there was an increase in the Roseburia species among them.

Obesity Review 27: 917-925

ARTICLE

2017 Poppitt SD. Hyperglycaemia, pre-diabetes and diabesity: can we choose who to ‘fast-track’ into diabetes prevention? An opinion piece on the methods used to diagnose pre-diabetes, the issues with screening, and what is necessary to be able to accurately identify and fast-track those patients most at risk.

Current Research in Diabetes & Obesity Journal 2(3): 555590

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2017 Poppitt SD. Obesity and weight control: is there light at the end of the tunnel? A review of the causative mechanisms of obesity, reasons for difficulty in achieving change thus far, and a call to better understand the gut-brain axis and the microbiome’s role in obesity if its prevelance is to diminish.

Current Nutrition Reports 6: 51-62

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2017 Sequeira IR, Poppitt SD. HbA1c as a marker of prediabetes: a reliable screening tool or not? A review of HbA1c as a screening tool for pre-diabetes. The authors suggest having a measure of fasting plasma glucose in addition to an HbA1c reading for diagnosis.

Insights in Nutrition & Metabolism 1(1): 21-29

ARTICLE

2017 Sequeira IR, Poppitt SD. Unfolding novel mechanisms of polyphenol flavonoids for better glycaemic control: targeting pancreatic islet amyloid polypeptide (IAPP) A review of the novel mechanistic ways dietary polyphenols suppress dysmorphic amylin – a protein involved in the pathogenesis of Type 2 Diabetes.

Nutrients 9(7): 788

ARTICLE

2017 Singh RG, Yoon HD, Poppitt SD, Plank LD, Petrov MS. Ectopic fat accumulation in the pancreas and its biomarkers: a systematic review and meta-analysis An analysis of the literature to determine biomarkers of pancreatic fat. Circulating triglycerides and glycated haemoglobin appear to be the best indicators in lieu of other more invasive methods.

Diabetes Metabolism Research and Reviews Journal 33(8): e2918

ARTICLE

2017 Yip W, Sequeira IR, Plank LD, Poppitt SD. Prevalence of pre-diabetes across ethnicities: a review of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) for classification of dysglycaemia A review of the differences between Caucasian and Asian population’s prevalence of pre-diabetes, using both the WHO and American Diabetes Association cutoffs.

Nutrients 9(11): 1273

ARTICLE

2015 Liu AY, Silvestre MP, Poppitt SD. Prevention of type 2 diabetes through lifestyle modification: is there a role for higher-protein diets A review of low fat, high carbohydrate diets in preventing type 2 diabetes with mechanistic reasons to consider why a moderate carbohydrate, high protein diet may be more effacious.

Advances in Nutrition 6(6): 665-673

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2015 Poppitt, SD. Beverage consumption – are alcoholic and sugary drinks tipping the balance towards overweight and obesity? A review of sugary drinks and alcohol on the expanding global waistline, with a critique of the interventional and observational studies which show conflicting results.

Nutrients 7(8): 6700-6718

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