Publications

Publications generated as a direct result of funding received from the High-Value Nutrition (HVN) National Science Challenge are listed below.  The HVN programmes are listed in alphabetical order, with their publications listed by year (most recent listed first) and alphabetically (using the first author’s last name).  Some programmes supported by HVN funds may not have publications listed because this is not part of their mission or because they are in early stages of work.  Please note, some publications below may be listed in two or more programmes – these represent inter-programme collaborations.

Digestive Health

 

Year Authors Title Summary Published
2020 Carco, C., Young, W., Heenan, P., Wall, C., Mullaney, J.A., Maclean, P.D., Cotter, P.D., Fraser, K., Gearry, R.B., McNabb, W.C. and Roy, N.C. Relative abundances of microbial genes involved in galactose and porphyrin metabolism are altered in diarrhea-predominant functional gastrointestinal disorders Study examining fecal samples from a case-control study to improve understanding of links between microbiome and functional gastrointestinal (GI) disorders. Results show that the relative abundance of taxa from the Clostridiales order,including Lachnospiraceae and Blautia, and genes related to the metabolism of galactose and porphyrin were positively correlated with GI symptoms related to diarrhea.

Gastroenterology 158(6)

ARTICLE

2020 Carco CMD, Young W, Gearry RB, Talley NJ, McNabb WC, and Roy NC. Increasing evidence that Irritable Bowel Syndrome and functional gastrointestinal disorders have a microbial pathogenesis Review discussing interplay between host factors, such as microbial dysbiosis, immune activation, impaired epithelial barrier function and motility, and environmental factors, including diet, in the pathophysiology of functional gastrointestinal disorders.

Frontiers in Cellular and Infection Microbiology

ARTICLE

2020 Heenan P, Creemers RH, Sharma S, Keenan J, Bayer S, Young W, Cooney J, Armstrong K, Fraser K, Skidmore PM, Talley NJ, COMFORT Cohort Collaborators, Roy NC, and Gearry RB. Cohort Profile – The Christchurch cOhort to investigate Mechanisms FOr gut Relief and improved Transit (COMFORT). Cross-sectional observational case-control study to increase understanding of functional gastrointestinal disorders (FGID). The COMFORT cohort is a unique clinical cohort of FGID cases, with future research aimed at using systems biology approaches to establish role of diet, host-microbiome interactions, and other factors in the pathogenesis of FGIDs.

Inflammatory Intestinal Diseases 5(3)

ARTICLE

2020 James SC, Fraser K, Young W, McNabb WC & Roy N. Gut metabolites and biochemical pathways involved in irritable bowel syndrome: effects of diet and nutrition on the microbiome. A review of the possible link between diet, metabolites and microbiota in those with functional gut disorders, particularly IBS.

Journal of Nutrition 150(5): 1012-1021

ARTICLE

2020 Milan AM, Shrestha A, Karlström HJ, Martinsson JA, Nilsson NJ, Perry JK, Day L, Barnett MPG, Cameron-Smith D. Comparison of the impact of bovine milk β-casein variants on digestive comfort in females self-reporting diary intolerance: a randomized controlled trial. a2 Milk™ decreased the severity of some lactose malabsorptive symptoms in lactose intolerant subjects. Furthermore, self-reported dairy intolerance without lactose malabsorption is identified in those with rapid, transient symptoms after milk ingestion, regardless of lactose or β-casein content.

American Journal of Clinical Nutrition 111(1): 149-160

ARTICLE

2020 Roy N, Heenan P, Wall C, Young W, Carco C, Keenan J, Cotter P, Maclean P, Mullaney J, Fraser K, James S, McNabb W, and Gearry R. Association of habitual dietary fiber intake and fecal microbiome gene abundance with gastrointestinal symptoms in an Irritable Bowel Syndrome cohort Study exploring differences in dietary fibre intake, gastrointestinal symptoms, and the fecal microbiome in those with functional gastrointestinal disorders (FGID). High fibre consumption was associated with decreased bloating, anxiety, and depression in different FGID subgroups. Irritable Bowel Syndrome was associated with altered fecal microbiome composition, including taxa linked to carbohydrate and hydrogen metabolism.

Current Developments in Nutrition 4(2):1581

ARTICLE

2020 Shrestha A, Barnett MPG, Perry JK, Cameron-Smith D, and Milan AM. Evaluation of breath, plasma, and urinary markers of lactose malabsorption to diagnose lactase non-persistence following lactose or milk ingestion Study to evaluate diagnostic accuracy to detect lactase non-persistence (LNP) using commonly measured lactose malabsorption (LM) markers after lactose and milk challenges. Accurate diagnosis of LNP by breath hydrogen was demonstrated irrespective of substrate used. Diagnostic threshold may vary depending on substrate.

BMC Gastroenterology 20(1):204

ARTICLE

2019 Bayer SB, Heenan P, Keenan J, Roy N, and Gearry RB. Evaluation of the psychosocial features of people with functional abdominal bloating (FAB) Study investigating the association between the symptoms of FAB and economic background in a cohort. Symptoms of FAB were associated with all subgroups of Irritable Bowel Syndrome, with higher bloating scores also correlating with lower standard of living.

Gastroenterology 156(6)

ARTICLE

2019 Brown SC, Whelan K, Gearry RB, Day AS. Low FODMAP diet in children and adolescents with functional bowel disorder: A clinical case note review. Study examining the use of the low FODMAP diet (LFD) in children with a functional bowel disorder (FBD). The LFD is a useful dietary treatment strategy for children with FBD, and the study adds to a body of evidence supporting FODMAP interventions in children with FBD.

JGH Open 4(2):153-159

ARTICLE

2019 Fraser K, Young W, McNabb, W, Gearry R & Roy N Lipid and metabolite profiles in human plasma and associations with the microbiome and functional gastrointestinal disorders Case-control study attempting to identify microbial and host factors in plasma to provide mechanistic insights into functional gastrointestinal (GI) disorders and increase predictability of phenotypes for use in nutrition intervention studies. Perturbations of plasma lipid concentrations in Irritable Bowel Syndrome subjects suggest changes may occur with both host and microbial lipid metabolism.

Current Developments in Nutrition 3(1)

ARTICLE

2019 Ghimeray PS, Shrestha A, Karlström J, Martinson J, Nilsson J, Barnett M, Cameron-Smith D, and Milan A. Riboflavin Bioavailability Varies with Milk Type and Is Altered in Self-Reported Dairy Intolerance States (P24-012-19). In this randomised cross-over controlled trial, the processing of milk was shown to affect plasma riboflavin levels as conventional milk showed greater levels in subjects than lactose free or A2 milk.

Current Developments in Nutrition 3(1)

ARTICLE

2019 Heenan PE, Keenan JI, Bayer S, Simon M & Gearry RB. Irritable bowel syndrome and the gut microbiota A review of the history and current understanding of gut microbiota relative to their role in the pathogenesis of irritable bowel syndrome.

Journal of the Royal Society of New Zealand 50(3): 470-490

ARTICLE

2019 James C, Fraser K, Young W, McNabb W, Gearry R, Roy N. Understanding how metabolites link diet, host, and microbiota in a dysfunctional gut model is important to establishing a system-wide understanding of gut function (P20-035-19). There was no difference in the bile acid concentrations in this cohort study of controls and IBS participants. However, bile acid profile differed significantly in the IBS cohort compared to healthy controls, suggesting that bile acid metabolism is perturbed in IBS.

Current Developments in Nutrition 3(1)

ARTICLE

2019 Kortlever TL, Ten Bokkel Huinink S, Offereins M, Hebblethwaite C, O’Brien L, Leeper J, Mulder CJJ, Barrett JS, Gearry RB. Low-FODMAP Diet Is Associated With Improved Quality of Life in IBS Patients-A Prospective Observational Study. Study aiming to determine the effect of low-FODMAP diet on long-term QoL, gastrointestinal (GI) and non-GI symptoms in Irritable Bowel Syndrome (IBS) patients. Low‐FODMAP diet was associated with improved long‐term QoL and GI symptoms, reduced fatigue and anxiety/depression, and increased happiness and vitality. Nutrition in Clinical Practice 34(4): 623-630

 

ARTICLE

2019 Shrestha A, Prodhan UK, Mitchell SM, Sharma P, Barnett MPG, Milan AM, Cameron-Smith D. Validity of a portable breath analyser (AIRE) for the assessment of lactose malabsorption. A portable breath analyser is successfully validated against a calibrated breath hydrogen analyser in participants experiencing lactose malabsorption.

Nutrients 11(7): 1636

ARTICLE

2019 Wright-McNaughton M, Ten Bokkel Huinink S, Frampton CMA, McCombie AM, Talley NJ, Skidmore PML, Gearry RB. Measuring Diet Intake and Gastrointestinal Symptoms in Irritable Bowel Syndrome: Validation of the Food and Symptom Times Diary A prospective observational study of the validity of a food and symptom diary. As a tool, the diary can measure gastrointestinal symptoms in those with IBS and correlate these to specific aspects of their diet.

Clinical and Translational Gastroenterology 10(12): e00103

ARTICLE

2019 Young, W., C. Carco, J. Mullaney, P. Maclean, P. Cotter, K. Fraser, W. McNabb, R. Gearry & N. Roy. The Microbiome in Functional Gastrointestinal Disorders Is Characterized by Bacteria and Genes Involved in Carbohydrate and Bile Acid Metabolism (OR23-01-19) Study undertaking shotgun metagenomic sequencing of fecal samples from a case-control study to improve understanding of links between microbiome and Irritable Bowel Syndrome (IBS). Results from the study suggest carbohydrate and bile acid metabolism by the gastrointestinal (GI) microbiome may be important distinguishing characteristics in functional GI disorders.

Current Developments in Nutrition 3(1)

ARTICLE

2019 Young W, Fraser K, Maclean P, Carco C, Mullaney J, Cotter P, McNabb W, Gearry R & Roy N Integrated multi-omics analysis of the faecal microbiome and plasma lipidome from a New Zealand Irritable Bowel Syndrome case/control study Study to examine link between microbiome and host lipid metabolism in Irritable Bowel Syndrome (IBS). Results show potential links between major members of fecal microbiome, in both composition and function, with the plasma lipidome profile in an IBS cohort.

Gastroenterology 156(6)

ARTICLE

 

 

Immune Health

 

Year Authors Title Summary Published
2020 Shaw O, Hurst R, Sawyer G, Dinnan H, and Martell S. Different immune and functional effects of urban dust and diesel particulate matter inhalation in a mouse model of acute air pollution exposure. Study to determine immune effects and lung function of acute exposure to two different pollution sources using a mouse model. Although both urban dust and diesel particulate matter induced immune cell infiltration into the lung resulting in lung inflammation, their detrimental effects on cytokine production and lung function were quite different. 

Immunology and Cell Biology

ARTICLE

2020 Tang JS, Compton BJ, Marshall A,  Anderson R, Li Y, van der Woude H, Hermans IF, Painter GF, Gasser O. Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells. This in vitro work demonstrates how methylglyoxal from Mānuka honey enhances the activation of antimicrobial MAIT cells of the immune system. This potentially posits Mānuka honey as an exogenous immune homeostatic modifier.

Food and Function 11: 5782-5787

ARTICLE

 

2019 Cong L, Bremer P, Mirosa M. Chinese Consumers’ Perceptions of Functional Foods: A Netnography Study of Foods that Help the Immune System Recover from Air Pollution Systematically using online searches to determine Chinese consumer views of effects of air pollution on their health and how food is used to remedy it, showed that respiratory impact was of most concern and traditional Chinese medicine and eating more fruits and vegetables were the main sought-after solutions.

Journal of Food Products Marketing 25(6): 628-646

ARTICLE

2019 Miller M, Puddick J, Symonds JE, Walker SP. Application of a Fourier transform—near infrared reflectance spectroscopy method for the rapid proximate analysis of the greenshell mussel (Perna canaliculus) and king (Chinook) salmon (Oncorhynchus tshawytscha) To perform rapid compositional analysis on greenshell mussel and king salmon, Fourier transform-near infrared reflectance spectroscopy was trialled. This study validates the method against classical “wet chemistry”, which is expensive, wasteful and time-consuming in comparison.

Aquaculture Research 50(6): 1668-1677

ARTICLE

2019 Siriarchavatana P, Kruger MC, Miller MR, Tian H, Wolber FM. The preventive effects of green shelled mussel on early-stage metabolic osteoarthritis in rats with diet-induced obesity This randomised controlled trial fed rats a normal diet or a high fat-high sugar diet, either supplemented with greenshell mussel powder or not. Those rats who received the greenshell mussel had lower concentrations of CTX-II, a biomarker involved in cartilage degeneration.

Nutrients 11(7): 1601

ARTICLE

2018 Miller MR and Tian H. Changes in proximate composition, lipid class and fatty acid profile in Greenshell™ mussels (Perna canaliculus) over an annual cycle Analysis of Greenshell mussels showed that the nutritional payload was lowest in mussels harvested in winter, and highest in female mussels prior to spawning in spring. These species are a rich source of iron, zinc, omega-3 fatty acids; understanding their composition is needed to maximise their export potential.

Aquaculture Research 49(3): 1153-1165

ARTICLE

2018 Shortt N, Poyntz H, Young W, Jones A, Gestin A, Mooney A, Thayabaran D, Sparks J, Ostapowicz T, Tay A, Poppitt SD, Elliott S, Wakefield G, Parry-Strong A, Ralston J, Gasser O, Beasley R, Weatherall M, Braithwaite I, Forbes-Blom E. A feasibility study: Association between Gut Microbiota Enterotype and Antibody Response to Seasonal Trivalent Influenza Vaccine in Adults Promisingly, the completion rate of the feasibility study is high, however certain exclusion criteria could limit recruitment. Further powered research on the relationship between microbiota composition and vaccine response is needed.

Clinical Translational Immunology 7(3): e1013 

ARTICLE

2017 van den Elsen LWJ, Poyntz H, Weyrich L, Young W, Forbes-Blom E. Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases A review looking at the effect of gut microbiota modulation on immunity, and the implications of altering the gut microbiota to improve inflammatory diseases.

Clinical & Translational Immunology 6(1): e125

ARTICLE

 

 

Infant Health

 

Year Authors Title Summary Reference
2020 Heath A, Haszard J, Galland B, Lawley B, Rehrer N, Drummond L, Sims I, Taylor R, Otal A, Taylor B, and Tannock G. Association between the faecal short-chain fatty acid propionate and infant sleep An assessment of whether short-chain fatty acids (from indigestible plant sugars) are associated with longer uninterrupted sleep in infants. A higher proportion of total faecal short-chain fatty acids was associated with longer uninterrupted infant sleep.

European Journal of Clinical Nutrition 74: 1362

ARTICLE

2020 McKeen S, Wall C, Eriksen H, Lovell A, Mullaney J, Young W, Fraser K, Roy N, McNabb W. Connecting Infant Complementary Feeding Patterns with Microbiome Development A look at the food groups that modulate the infant gut microbiome between 6 -12 months of age. Food intake data suggests that legumes, eggs, dairy, breastmilk and infant formula are most influential on microbial metabolic pathways.

Current Developments in Nutrition 4 (Suppl 2): 1034

ARTICLE

2019 McKeen S, Young W, Mullaney J, Fraser K, McNabb W, and Roy N. Infant Complementary Feeding of Prebiotics for the Microbiome and Immunity A review of introducing complex, non-digestible carbohydrates to infants during the stage of complementary feeding, which promotes intestinal barrier integrity and immune development.

Nutrients 11(2): 364

ARTICLE

2018 Michelini S, Balakrishnan B, Parolo S, Matone A, Mullaney J, Young W, Gasser O, Wall C, Priami C, Lombardo R, Kussmann M. A reverse metabolic approach to weaning: in silico identification of immune-beneficial infant gut bacteria, mining their metabolism for prebiotic feeds and sourcing these feeds in the natural product space Identification of an optimal weaning food for infant gut bacteria proliferation is determined by identifying the metabolite requirements of beneficial gut bacteria, determining the nutrients that contain these metabolites and, in turn, uncovering a potential ‘first food’ to boost the immune system of infants in the critical stage of complementary feeding.

Microbiome 6: 171

ARTICLE

 

 

Metabolic Health

 

Year Authors Title Summary Published
2020 Ramzan F, D’Souza RF, Durainayagam BR, Milan AM, Markworth JF, Miranda V, Soberanis, Sequeira IR, Roy NC, Poppitt SD, Mitchell CJ, Cameron-Smith D. Circulatory miRNA biomarkers of metabolic syndrome Two circulatory microRNAs are identifed as predictive markers of the metabolic syndrome in both men and women, demonstrating the role these molecules play in metabolic dysregulation.

Acta Diabetologica 57(2): 203-214

ARTICLE

2019 Wu Z, Kruger M, Cooper JS, Poppitt SD, Fraser K. Tissue-specific sample dilution: an important parameter to optimise prior to untargeted LC-MS metabolomics A matrix to determine suitable injected concentrations when using untargeted LC-MS.

Metabolites 9(7): 124

ARTICLE

2019 Davies NK, O’Sullivan JM, Plank LD, Murphy R. Altered gut microbiome after bariatric surgery and its association with metabolic benefits: A systematic review A systematic review of the various bariatric surgeries shows increased microbial diversity following surgery. Potential causes of confounding with diabetes remission is addressed.

Surgery for Obesity and Related Diseases 15(4): 656-665

ARTICLE

2019 Mishra S, Monro J. Timing of fruit ingestion and blood glucose response (P12-014-19) This randomised cross-over design trial used preloading of a wheat-based breakfast cereal or kiwifruit in equicarbohydrate portions to determine the effect of kiwifruit on the glycaemic response. Consuming kiwifruit 30 minutes before the cereal reduced the blood glucose ‘spike’ significantly.

Current Developments in Nutrition 3(1)

ARTICLE

2019 Sluik D, Brouwer-Brolsma EM, Berendsen AAM, Mikkilä V, Poppitt SD, Silvestre MP, Tremblay A, Pérusse L, Bouchard C, Raben A, Feskens EJM. Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project Higher protein intakes – in particular plant proteins – shows lower incidence of pre-diabetes and diabetes. All other associations became nonsignificant when adiposity was factored in.

American Journal of Clinical Nutrition 109(5): 1310-1318

ARTICLE

2018 Fadason T, Schierding W, Lumley T, O’Sullivan JM. Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities A multimorbidity atlas of traits is constructed to help determine the influence of variants, SNPs and phenotypes involved in the pathogenesis of non-communicable diseases.

Nature Communications 9: 5198

ARTICLE

2018 Silvestre MP, McMahon C, Goode JP, Tay A, Poppitt SD. Is there a role for glucagon in weight loss-mediated metabolic improvements? A meta-analysis of glucagon suppression after weight loss with bariatric surgery or diet found that glucagon decreased in parallel with weight loss, irrespective of method.

Obesity Review 19(2): 233-253

ARTICLE

2018 DeSouza SV, Singh RG, Yoon HD, Murphy R, Plank LD, Petrov MS. Pancreas volume in health and disease: a systematic review and meta-analysis Systematic review of  pancreas volume in both diseased and well states, using computer tomography and MRI. A larger pancreas is correlated to obesity; a smaller pancreas is consistent with Type 1 & 2 diabetes.

Expert Review Gastroenterology & Hepatology 12(8): 757-766

ARTICLE

2018 Lubransky A, Monro J, Mishra S, Yu H, Haszard J, Venn B. Postprandial Glycaemic, Hormonal and Satiety Responses to Rice and Kiwifruit Preloads in Chinese Adults: A Randomised Controlled Crossover Trial Splitting meals into two by preloading a rice meal with either rice itself or kiwifruit, demonstrated in this randomised cross-over trial that preloading of both kinds reduces postprandial glycaemia. When the meal was partially replaced by kiwifruit the insulin response was more effective also.

Nutrients 10(8): 1110

ARTICLE

2018 Monro J, Bentley-Hewitt K, Mishra S. Kiwifruit Exchanges for Increased Nutrient Richness with Little Effect on Carbohydrate Intake, Glycaemic Impact, or Insulin Response The nutrient density of kiwifruit enables it to be partially substituted for carbohydrate-rich foods without compromising on overall carbohydrate intake, glycaemic or insulin responses. This research compiled equi-carbohydrate substitution tables to aid dietary intervention.

Nutrients 10(11): 1710

ARTICLE

2018 Bermingham EN, Reis MG, Subbaraj AK, Cameron-Smith D, Fraser K, Jonker A, Craigie CR. Distribution of fatty acids and phospholipids in different table cuts and co-products from New Zealand pasture-fed Wagyu-dairy cross beef cattle Grass finished Wagyu-dairy cross beef has levels of omega-3 fatty acids and phospholipids to help meet dietary recommendations and play a role in cholesterol reduction. Co-products are richer in these nutrients than common table cuts.

Meat Science 140: 26-37

ARTICLE

2018 Lu LW, Monro J, Lu J, Rush E. The effect of cold treatment of parboiled rice with lowered glycaemic potency on consumer liking and acceptability Cold treatment reduces the post-prandial blood glucose response. Cold treated, reheated, parboiled rice rates highest on consumer liking and acceptability among common rice consumers.

Foods 7(12): pii: E207

ARTICLE

2017 Sequeira IR, Poppitt SD. Unfolding novel mechanisms of polyphenol flavonoids for better glycaemic control: targeting pancreatic islet amyloid polypeptide (IAPP) A review of the novel mechanistic ways dietary polyphenols suppress dysmorphic amylin – a protein involved in the pathogenesis of Type 2 Diabetes.

Nutrients 9(7): 788

ARTICLE

2017 Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice The published data-set for the below study about rutin and its suppression of human-amylin in transgenic mice.

Data in Brief 10: 298-303

ARTICLE

2017 Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice Human-amylin misfolds and aggregates causing β-cell apoptosis and diabetes progression. In human-amylin transgenic mice, the flavonol rutin suppressed aggregation in-vitro and mitigated the progression of diabetes in the mice.  

Biochemical and Biophysical Research Communications 482(4): 625-631

ARTICLE

2017 Poppitt SD. Obesity and weight control: is there light at the end of the tunnel? A review of the causative mechanisms of obesity, reasons for difficulty in achieving change thus far, and a call to better understand the gut-brain axis and the microbiome’s role in obesity if its prevelance is to diminish.

Current Nutrition Reports 6: 51-62

ARTICLE

2017 Sequeira IR, Poppitt SD. HbA1c as a marker of prediabetes: a reliable screening tool or not? A review of HbA1c as a screening tool for pre-diabetes. The authors suggest having a measure of fasting plasma glucose in addition to an HbA1c reading for diagnosis.

Insights in Nutrition & Metabolism 1(1): 21-29

ARTICLE

2017 Singh RG, Yoon HD, Poppitt SD, Plank LD, Petrov MS. Ectopic fat accumulation in the pancreas and its biomarkers: a systematic review and meta-analysis An analysis of the literature to determine biomarkers of pancreatic fat. Circulating triglycerides and glycated haemoglobin appear to be the best indicators in lieu of other more invasive methods.

Diabetes Metabolism Research and Reviews Journal 33(8): e2918

ARTICLE

2017 Murphy R, Tsai P, Jüllig M, Liu A, Plank L, Booth M. Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission Roux-en-Y surgery yielded greater microbiota composition changes post surgery than sleeve gastrectomy. An equal number of randomised patients had Type 2 diabetes remission; there was an increase in the Roseburia species among them.

Obesity Review 27: 917-925

ARTICLE

2017 Poppitt SD. Hyperglycaemia, pre-diabetes and diabesity: can we choose who to ‘fast-track’ into diabetes prevention? An opinion piece on the methods used to diagnose pre-diabetes, the issues with screening, and what is necessary to be able to accurately identify and fast-track those patients most at risk.

Current Research in Diabetes & Obesity Journal 2(3): 555590

ARTICLE

2017 Fadason T, Ekblad C, Ingram JR, Schierding W, O’Sullivan JM. Physical interactions and expression quantitative traits loci identify regulatory connections for obesity and Type 2 Diabetes associated SNPs A genetic look at the relationship between obesity and type 2 diabetes pathogenesis via the impact of known SNPs on genes and function in tissue types.

Frontiers in Genetics 8: 150

ARTICLE

2017 Yip W, Sequeira IR, Plank LD, Poppitt SD. Prevalence of pre-diabetes across ethnicities: a review of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) for classification of dysglycaemia A review of the differences between Caucasian and Asian population’s prevalence of pre-diabetes, using both the WHO and American Diabetes Association cutoffs.

Nutrients 9(11): 1273

ARTICLE

2017 Mishra S, Edwards H, Hedderley D, Podd J, Monro J. Kiwifruit non-sugar components reduce glycaemic response to co-ingested cereal in humans An RCT of the glycaemic response after consuming a wheat-based cereal with kiwifruit, guar gum and/or the sugar loading of kiwifruit (glucose). Hypoglycaemia only occurred in the glucose sample, suggesting non-sugar components of kiwifruit are responsible for the ameliorating effect on blood sugars.

Journal of Nutritional Science 9(11): 1195

ARTICLE

2016 Misra S, Willis J, Ansell J, Monro JA. Equicarbohydrate partial exchange of kiwifruit for wheaten cereal reduces postprandial glycaemia without decreasing satiety Eating certain varieties of kiwifruit concurrently with a wheat-based breakfast cereal (at a constant total carbohydrate intake) may benefit the glycaemic and homeostatic response but won’t impede satiety.

Journal of Nutritional Science 5: e37

ARTICLE

2015 Liu AY, Silvestre MP, Poppitt SD. Prevention of type 2 diabetes through lifestyle modification: is there a role for higher-protein diets A review of low fat, high carbohydrate diets in preventing type 2 diabetes with mechanistic reasons to consider why a moderate carbohydrate, high protein diet may be more effacious.

Advances in Nutrition 6(6): 665-673

ARTICLE

2015 Poppitt, SD. Beverage consumption – are alcoholic and sugary drinks tipping the balance towards overweight and obesity? A review of sugary drinks and alcohol on the expanding global waistline, with a critique of the interventional and observational studies which show conflicting results.

Nutrients 7(8): 6700-6718

ARTICLE

 

 

Science of Food

 

 

Year Authors Title Summary Published
2020 Acevedo-Fani A, Dave A, and Singh H. Nature-assembled structures for delivery of bioactive compounds and their potential in functional foods Review discussing the structure and biological function of different nature-assembled carriers, preparation/isolation methods, some of the advantages and challenges in their use as bioactive compound delivery systems, and their behavior during digestion.

Frontiers in Chemistry: Physical Chemistry and Chemical Physics

ARTICLE

 

2020 Le HD, Loveday SM, Nowak E, Niu Z, and Singh H. Pectin emulsions for colon-targeted release of propionic acid Study assessing a designed emulsion system’s ability to resist gastric and intestinal digestion for targeted delivery of compounds. Pectin concentrations of >2.5 wt% improved the emulsion’s resistance to coalescence, reducing the rate of lipolysis and degree of hydrolysis. Use of pectin to form resistant emulsions has potential as an approach to delay digestion.

Food Hydrocolloids

ARTICLE

2020 Niu Z, Acevedo-Fani A, McDowell A, Barnett A, Loveday SM, and Singh H. Nanoemulsion structure and food matrix determine the gastrointestinal fate and in-vivo bioavailability of coenzyme Q10 Study assessing impact of food digestion on bioavailability of coenzyme Q10 when loaded into nanoemulsions in a beverage. Encapsulated coenzyme Q10 bioavailability increased 2.8-fold as part of the beverage. Food digestion (e.g. lipolysis) can substantially influence absorption of hydrophobic bioactive components.

Journal of Controlled Release 327:444

ARTICLE

2020 Niu Z, Thielen I, Dave A, Loveday SM, and Singh H. Emulsions stabilised by polyethylene glycol (PEG) 40 stearate and lactoferrin for protection of lactoferrin during digestion Study assessing whether bioactive proteins at the interface of emulsions can be protected by PEG chains during in-vitro gastrointestinal digestion. After 2 hours of gastric digestion, 84% of lactoferrin in PEG emulsions was protected. PEG 40 shows promise as a food-grade emulsifier to prevent premature gastric digestion of bioactive proteins.

Food Biophysics

ARTICLE

2019 Nowak E, Livney Y, Niu Z, and Singh H. Delivery of bioactives in food for optimal efficacy: what inspirations and insights can be gained from pharmaceuticals? Review of the state of the art of delivery systems for bioactive compounds in food, including discussion of concepts used in drug delivery.

Trends in Food Science & Technology 91:557

ARTICLE

2019 Niu Z, Loveday S, Barbe V, Thielen I, He Y, and Singh H. Protection of native lactoferrin under gastric conditions through complexation with pectin and chitosan. Study assessing digestive fate of lactoferrin encapsulated in pectin-based colloidal system with and without chitosan. Both pectin and chitosan systems retained >90% of the lactoferrin, with chitosan-coated complexes also delaying degradation of released lactoferrin.

Food Hydrocolloids 93:120

ARTICLE

2019 Niu Z, Thielen I, Barnett A, Loveday S, and Singh H. ε-Polylysine and β-cyclodextrin assembling as delivery systems for gastric protection of proteins and possibility to enhance intestinal permeation Study assessing a nanocomplex’s capacity to entrap proteins for gastric protection. Up to 100% entrapment was achieved, contingent on protein type. Nanocomplexes were able to protect against proteolysis, and results indicate they have potential to enhance paracellular permeability of bioactive macromolecules.

Journal of Colloid and Interface Science 546:312

ARTICLE

2019 Rashidinejad A, Loveday SM, Jameson GB, Hindmarsh JP, and Singh H. Rutin-casein co-precipitates as potential delivery vehicles for flavonoid rutin Study to develop a cost-effective, biocompatible, and biodegradable delivery system for rutin (polyphenolic compound). Results indicated that appropriate pH-treatment of rutin and co-precipitation with sodium caseinate in presence or absence of trehalose resulted in powder suitable as a delivery system for rutin-fortified foods.

Food Hydrocolloids 96:451

ARTICLE