Publications

Digestive Health

 

 

 

Year Authors Title Summary Published
2020 Milan AM, Shrestha A, Karlström HJ, Martinsson JA, Nilsson NJ, Perry JK, Day L, Barnett MPG, Cameron-Smith D. Comparison of the impact of bovine milk β-casein variants on digestive comfort in females self-reporting diary intolerance: a randomized controlled trial. a2 Milk™ decreased the severity of some lactose malabsorptive symptoms in lactose intolerant subjects. Furthermore, self-reported dairy intolerance without lactose malabsorption is identified in those with rapid, transient symptoms after milk ingestion, irregardless of lactose or β-casein content.

American Journal of Clinical Nutrition 111(1): 149-160

ARTICLE

2019 Ghimeray PS, Shrestha A, Karlström J, Martinson J, Nilsson J, Barnett M, Cameron-Smith D, and Milan A.  Riboflavin Bioavailability Varies with Milk Type and Is Altered in Self-Reported Dairy Intolerance States (P24-012-19). In this randomised cross-over controlled trial, the processing of milk was shown to affect plasma riboflavin levels as conventional milk showed greater levels in subjects than lactose free or A2 milk.

Current Developments in Nutrition 3(1)

ARTICLE

2019 Shrestha A, Prodhan UK, Mitchell SM, Sharma P, Barnett MPG, Milan AM, Cameron-Smith D. Validity of a portable breath analyser (AIRE) for the assessment of lactose malabsorption. A portable breath analyser is successfully validated against a calibrated breath hydrogen analyser in participants experiencing lactose malabsorption.

Nutrients 11(7): 1636

ARTICLE

2019 James C, Fraser K, Young W, McNabb W, Gearry R, Roy N. Understanding how metabolites link diet, host, and microbiota in a dysfunctional gut model is important to establishing a system-wide understanding of gut function (P20-035-19). There was no difference in the bile acid concentrations in this cohort study of controls and IBS participants. However, bile acid profile differed significantly in the IBS cohort compared to healthy controls, suggesting that bile acid metabolism is perturbed in IBS.

Current Developments in Nutrition 3(1)

ARTICLE

2019 Wright-McNaughton M, Ten Bokkel Huinink S, Frampton CMA, McCombie AM, Talley NJ, Skidmore PML, Gearry RB. Measuring Diet Intake and Gastrointestinal Symptoms in Irritable Bowel Syndrome: Validation of the Food and Symptom Times Diary A prospective observational study of the validity of a food and symptom diary. As a tool, the diary can measure gastrointestinal symptoms in those with IBS and correlate these to specific aspects of their diet.

Clinical and Translational Gastroenterology 10(12): e00103

ARTICLE

2019 James SC, Fraser K, Young W, McNabb WC & Roy N. Gut metabolites and biochemical pathways involved in irritable bowel syndrome: effects of diet and nutrition on the microbiome. A review of the possible link between diet, metabolites and microbiota in those with functional gut disorders, particularly IBS.

Journal of Nutrition 150(5): 1012-1021

ARTICLE

2019 Tannock G, Liu Y. Guided dietary fibre intake as a means of directing short-chain fatty acid production by the gut microbiota A review on the complexity of microbiota utilising dietary fibre and producing short-chain fatty acids for overall health benefits.

Journal of the Royal Society of New Zealand 50(3): 434-455

ARTICLE

2019 Heenan PE, Keenan JI, Bayer S, Simon M & Gearry RB. Irritable bowel syndrome and the gut microbiota A review of the history and current understanding of gut microbiota relative to their role in the pathogenesis of irritable bowel syndrome.

Journal of the Royal Society of New Zealand 50(3): 470-490

ARTICLE

 

 

Immune Health

 

Year Authors Title Summary Published
2020 Tang, J.S., Compton, B.J., Marshall, A.,  Anderson, R., Li, Y., van der Woude, H., Hermans, I.F., Painter, G.F., and Gasser, O. DOI: https://10.1039/d0fo01153c Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells.   

Food and Function

2019 Miller M, Puddick J, Symonds JE, Walker SP. Application of a Fourier transform—near infrared reflectance spectroscopy method for the rapid proximate analysis of the greenshell mussel (Perna canaliculus) and king (Chinook) salmon (Oncorhynchus tshawytscha) To perform rapid compositional analysis on greenshell mussel and king salmon, Fourier transform-near infrared reflectance spectroscopy was trialled. This study validates the method against classical “wet chemistry”, which is expensive, wasteful and time-consuming in comparison.

Aquaculture Research 50(6): 1668-1677

ARTICLE

2019 Siriarchavatana P, Kruger MC, Miller MR, Tian H, Wolber FM. The preventive effects of green shelled mussel on early-stage metabolic osteoarthritis in rats with diet-induced obesity This randomised controlled trial fed rats a normal diet or a high fat-high sugar diet, either supplemented with greenshell mussel powder or not. Those rats who received the greenshell mussel had lower concentrations of CTX-II, a biomarker involved in cartilage degeneration.

Nutrients 11(7): 1601

ARTICLE

2019 Cong L, Bremer P, Mirosa M. Chinese Consumers’ Perceptions of Functional Foods: A Netnography Study of Foods that Help the Immune System Recover from Air Pollution Systematically using online searches to determine Chinese consumer views of effects of air pollution on their health and how food is used to remedy it, showed that respiratory impact was of most concern and traditional Chinese medicine and eating more fruits and vegetables were the main sought-after solutions.

Journal of Food Products Marketing 25(6): 628-646

ARTICLE

2019 Poyntz H, Jones A, Jauregui R, Young W, Gestin A, Mooney A, Lamiable O, Altermann E, Schmidt A, Gasser O, Weyrich L, Jolly C, Linterman M, LeGros G, Hawkins E, Forbes-Blom E. Genetic regulation of antibody responsiveness to immunization in substrains of BALB/c mice To help elucidate the heterogeneity of vaccine responsiveness amongst humans, different substrains of mice are investigated. Notably, antibody response phenotypes are not altered by microbiota composition, and differentially sourced mice have significant variation in their humoral immune responses.

Immunology & Cell Biology 97(1): 39-53

ARTICLE

2018 Shortt N, Poyntz H, Young W, Jones A, Gestin A, Mooney A, Thayabaran D, Sparks J, Ostapowicz T, Tay A, Poppitt SD, Elliott S, Wakefield G, Parry-Strong A, Ralston J, Gasser O, Beasley R, Weatherall M, Braithwaite I, Forbes-Blom E. Feasibility study: Association between Gut Microbiota Enterotype and Antibody Response to Seasonal Trivalent Influenza Vaccine in Adults Promisingly, the completion rate of the feasibility study is high, however certain exclusion criteria could limit recruitment. Further powered research on the relationship between microbiota composition and vaccine response is needed.

Clinical Translational Immunology 7(3): e1013 

ARTICLE

2018 Miller MR and Tian H. Changes in proximate composition, lipid class and fatty acid profile in Greenshell™ mussels (Perna canaliculus) over an annual cycle Analysis of Greenshell mussels showed that the nutritional payload was lowest in mussels harvested in winter, and highest in female mussels prior to spawning in spring. These species are a rich source of iron, zinc, omega-3 fatty acids; understanding their composition is needed to maximise their export potential.

Aquaculture Research 49(3): 1153-1165

ARTICLE

2017 van den Elsen LWJ, Poyntz H, Weyrich L, Young W, Forbes-Blom E. Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases A review looking at the effect of gut microbiota modulation on immunity, and the implications of altering the gut microbiota to improve inflammatory diseases.

Clinical & Translational Immunology 6(1): e125

ARTICLE

 

 

Infant Health

 

Year Authors Title Summary Reference
2020 McKeen S, Wall C, Eriksen H, Lovell A, Mullaney J, Young W, Fraser K, Roy N, McNabb W. Connecting Infant Complementary Feeding Patterns with Microbiome Development A look at the food groups that modulate the infant gut microbiome between 6 -12 months of age. Food intake data suggests that legumes, eggs, dairy, breastmilk and infant formula are most influential on microbial metabolic pathways.

Current Developments in Nutrition 4 (Suppl 2): 1034

ARTICLE

2019 McKeen S, Young W, Mullaney J, Fraser K, McNabb W, and Roy N. Infant Complementary Feeding of Prebiotics for the Microbiome and Immunity A review of introducing complex, non-digestable carbohydrates to infants during the stage of complementary feeding, which promotes intestinal barrier integrity and immune development.

Nutrients 11(2): 364

ARTICLE

2018 Michelini S, Balakrishnan B, Parolo S, Matone A, Mullaney J, Young W, Gasser O, Wall C, Priami C, Lombardo R, Kussmann M. A reverse metabolic approach to weaning: in silico identification of immune-beneficial infant gut bacteria, mining their metabolism for prebiotic feeds and sourcing these feeds in the natural product space Identification of an optimal weaning food for infant gut bacteria proliferation is determined by identifying the metabolite requirements of beneficial gut bacteria, determining the nutrients that contain these metabolites and, in turn, uncovering a potential ‘first food’ to boost the immune system of infants in the critical stage of complementary feeding.

Microbiome 6: 171

ARTICLE

 

 

Metabolic Health

 

Year Authors Title Summary Published
2020 Ramzan F, D’Souza RF, Durainayagam BR, Milan AM, Markworth JF, Miranda V, Soberanis, Sequeira IR, Roy NC, Poppitt SD, Mitchell CJ, Cameron-Smith D. Circulatory miRNA biomarkers of metabolic syndrome Two circulatory microRNAs are identifed as predictive markers of the metabolic syndrome in both men and women, demonstrating the role these molecules play in metabolic dysregulation.

Acta Diabetologica 57(2): 203-214

ARTICLE

2019 Wu Z, Kruger M, Cooper JS, Poppitt SD, Fraser K. Tissue-specific sample dilution: an important parameter to optimise prior to untargeted LC-MS metabolomics A matrix to determine suitable injected concentrations when using untargeted LC-MS.

Metabolites 9(7): 124

ARTICLE

2019 Davies NK, O’Sullivan JM, Plank LD, Murphy R. Altered gut microbiome after bariatric surgery and its association with metabolic benefits: A systematic review A systematic review of the various bariatric surgeries shows increased microbial diversity following surgery. Potential causes of confounding with diabetes remission is addressed.

Surgery for Obesity and Related Diseases 15(4): 656-665

ARTICLE

2019 Mishra S, Monro J. Timing of fruit ingestion and blood glucose response (P12-014-19) This randomised cross-over design trial used preloading of a wheat-based breakfast cereal or kiwifruit in equicarbohydrate portions to determine the effect of kiwifruit on the glycaemic response. Consuming kiwifruit 30 minutes before the cereal reduced the blood glucose ‘spike’ significantly.

Current Developments in Nutrition 3(1)

ARTICLE

2019 Sluik D, Brouwer-Brolsma EM, Berendsen AAM, Mikkilä V, Poppitt SD, Silvestre MP, Tremblay A, Pérusse L, Bouchard C, Raben A, Feskens EJM. Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project Higher protein intakes – in particular plant proteins – shows lower incidence of pre-diabetes and diabetes. All other associations became nonsignificant when adiposity was factored in.

American Journal of Clinical Nutrition 109(5): 1310-1318

ARTICLE

2018 Fadason T, Schierding W, Lumley T, O’Sullivan JM. Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities A multimorbidity atlas of traits is constructed to help determine the influence of variants, SNPs and phenotypes involved in the pathogenesis of non-communicable diseases.

Nature Communications 9: 5198

ARTICLE

2018 Silvestre MP, McMahon C, Goode JP, Tay A, Poppitt SD. Is there a role for glucagon in weight loss-mediated metabolic improvements? A meta-analysis of glucagon suppression after weight loss with bariatric surgery or diet found that glucagon decreased in parallel with weight loss, irrespective of method.

Obesity Review 19(2): 233-253

ARTICLE

2018 DeSouza SV, Singh RG, Yoon HD, Murphy R, Plank LD, Petrov MS. Pancreas volume in health and disease: a systematic review and meta-analysis Systematic review of  pancreas volume in both diseased and well states, using computer tomography and MRI. A larger pancreas is correlated to obesity; a smaller pancreas is consistent with Type 1 & 2 diabetes.

Expert Review Gastroenterology & Hepatology 12(8): 757-766

ARTICLE

2018 Lubransky A, Monro J, Mishra S, Yu H, Haszard J, Venn B. Postprandial Glycaemic, Hormonal and Satiety Responses to Rice and Kiwifruit Preloads in Chinese Adults: A Randomised Controlled Crossover Trial Splitting meals into two by preloading a rice meal with either rice itself or kiwifruit, demonstrated in this randomised cross-over trial that preloading of both kinds reduces postprandial glycaemia. When the meal was partially replaced by kiwifruit the insulin response was more effective also.

Nutrients 10(8): 1110

ARTICLE

2018 Monro J, Bentley-Hewitt K, Mishra S. Kiwifruit Exchanges for Increased Nutrient Richness with Little Effect on Carbohydrate Intake, Glycaemic Impact, or Insulin Response The nutrient density of kiwifruit enables it to be partially substituted for carbohydrate-rich foods without compromising on overall carbohydrate intake, glycaemic or insulin responses. This research compiled equi-carbohydrate substitution tables to aid dietary intervention. 

Nutrients 10(11): 1710

ARTICLE

2018 Bermingham EN, Reis MG, Subbaraj AK, Cameron-Smith D, Fraser K, Jonker A, Craigie CR. Distribution of fatty acids and phospholipids in different table cuts and co-products from New Zealand pasture-fed Wagyu-dairy cross beef cattle Grass finished Wagyu-dairy cross beef has levels of omega-3 fatty acids and phospholipids to help meet dietary recommendations and play a role in cholesterol reduction. Co-products are richer in these nutrients than common table cuts.

Meat Science 140: 26-37

ARTICLE

2018 Lu LW, Monro J, Lu J, Rush E. The effect of cold treatment of parboiled rice with lowered glycaemic potency on consumer liking and acceptability Cold treatment reduces the post-prandial blood glucose response. Cold treated, reheated, parboiled rice rates highest on consumer liking and acceptability among common rice consumers.

Foods 7(12): pii: E207

ARTICLE

2017 Sequeira IR, Poppitt SD. Unfolding novel mechanisms of polyphenol flavonoids for better glycaemic control: targeting pancreatic islet amyloid polypeptide (IAPP) A review of the novel mechanistic ways dietary polyphenols suppress dysmorphic amylin – a protein involved in the pathogenesis of Type 2 Diabetes.

Nutrients 9(7): 788

ARTICLE

2017 Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice The published data-set for the below study about rutin and its suppression of human-amylin in transgenic mice.

Data in Brief 10: 298-303

ARTICLE

2017 Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice Human-amylin misfolds and aggregates causing β-cell apoptosis and diabetes progression. In human-amylin transgenic mice, the flavonol rutin suppressed aggregation in-vitro and mitigated the progression of diabetes in the mice.  

Biochemical and Biophysical Research Communications 482(4): 625-631

ARTICLE

2017 Poppitt SD. Obesity and weight control: is there light at the end of the tunnel? A review of the causative mechanisms of obesity, reasons for difficulty in achieving change thus far, and a call to better understand the gut-brain axis and the microbiome’s role in obesity if its prevelance is to diminish.

Current Nutrition Reports 6: 51-62

ARTICLE

2017 Sequeira IR, Poppitt SD. HbA1c as a marker of prediabetes: a reliable screening tool or not? A review of HbA1c as a screening tool for pre-diabetes. The authors suggest having a measure of fasting plasma glucose in addition to an HbA1c reading for diagnosis.

Insights in Nutrition & Metabolism 1(1): 21-29 

ARTICLE

2017 Singh RG, Yoon HD, Poppitt SD, Plank LD, Petrov MS. Ectopic fat accumulation in the pancreas and its biomarkers: a systematic review and meta-analysis An analysis of the literature to determine biomarkers of pancreatic fat. Circulating triglycerides and glycated haemoglobin appear to be the best indicators in lieu of other more invasive methods.

Diabetes Metabolism Research and Reviews Journal 33(8): e2918

ARTICLE

2017 Murphy R, Tsai P, Jüllig M, Liu A, Plank L, Booth M. Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission Roux-en-Y surgery yielded greater microbiota composition changes post surgery than sleeve gastrectomy. An equal number of randomised patients had Type 2 diabetes remission; there was an increase in the Roseburia species among them.

Obesity Review 27: 917-925

ARTICLE

2017 Poppitt SD. Hyperglycaemia, pre-diabetes and diabesity: can we choose who to ‘fast-track’ into diabetes prevention? An opinion piece on the methods used to diagnose pre-diabetes, the issues with screening, and what is necessary to be able to accurately identify and fast-track those patients most at risk.

Current Research in Diabetes & Obesity Journal 2(3): 555590

ARTICLE

2017 Fadason T, Ekblad C, Ingram JR, Schierding W, O’Sullivan JM. Physical interactions and expression quantitative traits loci identify regulatory connections for obesity and Type 2 Diabetes associated SNPs A genetic look at the relationship between obesity and type 2 diabetes pathogenesis via the impact of known SNPs on genes and function in tissue types.

Frontiers in Genetics 8: 150

ARTICLE

2017 Yip W, Sequeira IR, Plank LD, Poppitt SD. Prevalence of pre-diabetes across ethnicities: a review of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) for classification of dysglycaemia A review of the differences between Caucasian and Asian population’s prevalence of pre-diabetes, using both the WHO and American Diabetes Association cutoffs.

Nutrients 9(11): 1273

ARTICLE

2017 Mishra S, Edwards H, Hedderley D, Podd J, Monro J. Kiwifruit non-sugar components reduce glycaemic response to co-ingested cereal in humans An RCT of the glycaemic response after consuming a wheat-based cereal with kiwifruit, guar gum and/or the sugar loading of kiwifruit (glucose). Hypoglycaemia only occurred in the glucose sample, suggesting non-sugar components of kiwifruit are responsible for the ameliorating effect on blood sugars.

Journal of Nutritional Science 9(11): 1195

ARTICLE

2016 Misra S, Willis J, Ansell J, Monro JA. Equicarbohydrate partial exchange of kiwifruit for wheaten cereal reduces postprandial glycaemia without decreasing satiety Eating certain varieties of kiwifruit concurrently with a wheat-based breakfast cereal (at a constant total carbohydrate intake) may benefit the glycaemic and homeostatic response but won’t impede satiety.

Journal of Nutritional Science 5: e37

ARTICLE

2015 Liu AY, Silvestre MP, Poppitt SD. Prevention of type 2 diabetes through lifestyle modification: is there a role for higher-protein diets A review of low fat, high carbohydrate diets in preventing type 2 diabetes with mechanistic reasons to consider why a moderate carbohydrate, high protein diet may be more effacious.

Advances in Nutrition 6(6): 665-673

ARTICLE

2015 Poppitt, SD. Beverage consumption – are alcoholic and sugary drinks tipping the balance towards overweight and obesity? A review of sugary drinks and alcohol on the expanding global waistline, with a critique of the interventional and observational studies which show conflicting results.

Nutrients 7(8): 6700-6718

ARTICLE