Immune Health


Year Authors Title Summary Published DOI
2019 Poyntz H, Jones A, Jauregui R, Young W, Gestin A, Mooney A, Lamiable O, Altermann E, Schmidt A, Gasser O, Weyrich L, Jolly C, Linterman M, LeGros G, Hawkins E, Forbes-Blom E. Genetic regulation of antibody responsiveness to immunization in substrains of BALB/c mice To help elucidate the heterogeneity of vaccine responsiveness amongst humans, different substrains of mice are investigated. Notably, antibody response phenotypes are not altered by microbiota composition, and differentially sourced mice have significant variation in their humoral immune responses. Immunology & Cell Biology 10.1111/imcb.12199
2018 Shortt N, Poyntz H, Young W, Jones A, Gestin A, Mooney A, Thayabaran D, Sparks J, Ostapowicz T, Tay A, Poppitt SD, Elliott S, Wakefield G, Parry-Strong A, Ralston J, Gasser O, Beasley R, Weatherall M, Braithwaite I, Forbes-Blom E. Feasibility study: Association between Gut Microbiota Enterotype and Antibody Response to Seasonal Trivalent Influenza Vaccine in Adults Promisingly, the completion rate of the feasibility study is high, however certain exclusion criteria could limit recruitment. Further powered research on the relationship between microbiota composition and vaccine response is needed. Clinical Translational Immunology 10.1002/cti2.1013
2017 van den Elsen LWJ, Poyntz H, Weyrich L, Young W, Forbes-Blom E. Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases A review looking at the effect of gut microbiota modulation on immunity, and the implications of altering the gut microbiota to improve inflammatory diseases. Clinical & Translational Immunology 10.1038/cti.2016.91



Metabolic Health


Year Authors Title Summary Published DOI
2020 Ramzan F, D’Souza RF, Durainayagam BR, Milan AM, Markworth JF, Miranda V, Soberanis, Sequeira IR, Roy NC, Poppitt SD, Mitchell CJ, Cameron-Smith D. Circulatory miRNA biomarkers of metabolic syndrome Two circulatory microRNAs are identifed as predictive markers of the metabolic syndrome in both men and women, demonstrating the role these molecules play in metabolic dysregulation. Acta Diabetologica



2019 Wu Z, Kruger M, Cooper JS, Poppitt SD, Fraser K. Tissue-specific sample dilution: an important parameter to optimise prior to untargeted LC-MS metabolomics A matrix to determine suitable injected concentrations when using untargeted LC-MS Metabolites



2019 Davies NK, O’Sullivan JM, Plank LD, Murphy R. Altered gut microbiome after bariatric surgery and its association with metabolic benefits: A systematic review A systematic review of the various bariatric surgeries shows increased microbial diversity following surgery. Potential causes of confounding with diabetes remission is addressed. Surgery for Obesity and Related Diseases



2019 Sluik D, Brouwer-Brolsma EM, Berendsen AAM, Mikkilä V, Poppitt SD, Silvestre MP, Tremblay A, Pérusse L, Bouchard C, Raben A, Feskens EJM. Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project Higher protein intakes – in particular plant proteins – shows lower incidence of pre-diabetes and diabetes. All other associations became nonsignificant when adiposity was factored in. American Journal of Clinical Nutrition



2018 Fadason T, Schierding W, Lumley T, O’Sullivan JM. Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities A multimorbidity atlas of traits is constructed to help determine the influence of variants, SNPs and phenotypes involved in the pathogenesis of non-communicable diseases. Nature Communications



2018 Silvestre MP, McMahon C, Goode JP, Tay A, Poppitt SD. Is there a role for glucagon in weight loss-mediated metabolic improvements? A meta-analysis of glucagon suppression after weight loss with bariatric surgery or diet found that glucagon decreased in parallel with weight loss, irrespective of method. Obesity Review 10.1111/obr.12631
2018 DeSouza SV, Singh RG, Yoon HD, Murphy R, Plank LD, Petrov MS. Pancreas volume in health and disease: a systematic review and meta-analysis Systematic review of  pancreas volume in both diseased and well states, using computer tomography and MRI. A larger pancreas is correlated to obesity; a smaller pancreas is consistent with Type 1 & 2 diabetes. Expert Review Gastroenterology & Hepatology




2018 Bermingham EN, Reis MG, Subbaraj AK, Cameron-Smith D, Fraser K, Jonker A, Craigie CR. Distribution of fatty acids and phospholipids in different table cuts and co-products from New Zealand pasture-fed Wagyu-dairy cross beef cattle Grass finished Wagyu-dairy cross beef has levels of omega-3 fatty acids and phospholipids to help meet dietary recommendations and play a role in cholesterol reduction. Co-products are richer in these nutrients than common table cuts. Meat Science




2018 Lu LW, Monro J, Lu J, Rush E. The effect of cold treatment of parboiled rice with lowered glycaemic potency on consumer liking and acceptability Cold treatment reduces the post-prandial blood glucose response. Cold treated, reheated, parboiled rice rates highest on consumer liking and acceptability among common rice consumers. Foods



2017 Sequeira IR, Poppitt SD. Unfolding novel mechanisms of polyphenol flavonoids for better glycaemic control: targeting pancreatic islet amyloid polypeptide (IAPP) A review of the novel mechanistic ways dietary polyphenols suppress dysmorphic amylin – a protein involved in the pathogenesis of Type 2 Diabetes. Nutrients



2017 Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice The published data-set for the below study about rutin and its suppression of human-amylin in transgenic mice. Data in Brief



2017 Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice Human-amylin misfolds and aggregates causing β-cell apoptosis and diabetes progression. In human-amylin transgenic mice, the flavonol rutin suppressed aggregation in-vitro and mitigated the progression of diabetes in the mice.   Biochemical and Biophysical Research Communications



2017 Poppitt SD. Obesity and weight control: is there light at the end of the tunnel? A review of the causative mechanisms of obesity, reasons for difficulty in achieving change thus far, and a call to better understand the gut-brain axis and the microbiome’s role in obesity if its prevelance is to diminish. Current Nutrition Reports



2017 Sequeira IR, Poppitt SD. HbA1c as a marker of prediabetes: a reliable screening tool or not? A review of HbA1c as a screening tool for pre-diabetes. The authors suggest having a measure of fasting plasma glucose in addition to an HbA1c reading for diagnosis. Insights in Nutrition & Metabolism


2017 Singh RG, Yoon HD, Poppitt SD, Plank LD, Petrov MS. Ectopic fat accumulation in the pancreas and its biomarkers: a systematic review and meta-analysis An analysis of the literature to determine biomarkers of pancreatic fat. Circulating triglycerides and glycated haemoglobin appear to be the best indicators in lieu of other more invasive methods. Diabetes Metabolism Research and Reviews Journal 10.1002/dmrr.2918
2017 Murphy R, Tsai P, Jüllig M, Liu A, Plank L, Booth M. Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission Roux-en-Y surgery yielded greater microbiota composition changes post surgery than sleeve gastrectomy. An equal number of randomised patients had Type 2 diabetes remission; there was an increase in the Roseburia species among them. Obesity Review



2017 Poppitt SD. Hyperglycaemia, pre-diabetes and diabesity: can we choose who to ‘fast-track’ into diabetes prevention? An opinion piece on the methods used to diagnose pre-diabetes, the issues with screening, and what is necessary to be able to accurately identify and fast-track those patients most at risk.

Current Research in Diabetes & Obesity Journal

10.19080/ CRDOJ.


2017 Fadason T, Ekblad C, Ingram JR, Schierding W, O’Sullivan JM. Physical interactions and expression quantitative traits loci identify regulatory connections for obesity and Type 2 Diabetes associated SNPs A genetic look at the relationship between obesity and type 2 diabetes pathogenesis via the impact of known SNPs on genes and function in tissue types. Frontiers in Genetics



2017 Yip W, Sequeira IR, Plank LD, Poppitt SD. Prevalence of pre-diabetes across ethnicities: a review of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) for classification of dysglycaemia A review of the differences between Caucasian and Asian populations prevalence of pre-diabetes, using both the WHO and American Diabetes Association cutoffs. Nutrients 10.3390/nu9111273
2017 Mishra S, Edwards H, Hedderley D, Podd J, Monro J Kiwifruit non-sugar components reduce glycaemic response to co-ingested cereal in humans An RCT of the glycaemic response after consuming a wheat-based cereal with kiwifruit, guar gum and/or the sugar loading of kiwifruit (glucose). Hypoglycaemia only occurred in the glucose sample, suggesting non-sugar components of kiwifruit are responsible for the ameliorating effect on blood sugars.

Journal of Nutritional Science

2016 Misra S, Willis J, Ansell J, Monro JA. Equicarbohydrate partial exchange of kiwifruit for wheaten cereal reduces postprandial glycaemia without decreasing satiety Eating certain varieties of kiwifruit concurrently with a wheat-based breakfast cereal (at a constant total carbohydrate intake) may benefit the glycaemic and homeostatic response but won’t impede satiety. Journal of Nutritional Science


2015 Liu AY, Silvestre MP, Poppitt SD. Prevention of type 2 diabetes through lifestyle modification: is there a role for higher-protein diets A review of low fat, high carbohydrate diets in preventing type 2 diabetes with mechanistic reasons to consider why a moderate carbohydrate, high protein diet may be more effacious. Advances in Nutrition



2015 Poppitt, SD Beverage consumption – are alcoholic and sugary drinks tipping the balance towards overweight and obesity? A review of sugary drinks and alcohol on the expanding global waistline, with a critique of the interventional and observational studies which show conflicting results.  Nutrients 10.3390/nu7085304



Digestive Health


Year Authors Title Summary Published DOI
2020 Milan AM, Shrestha A, Karlström HJ, Martinsson JA, Nilsson NJ, Perry JK, Day L, Barnett MPG, Cameron-Smith D. Comparison of the impact of bovine milk β-casein variants on digestive comfort in females self-reporting diary intolerance: a randomized controlled trial. a2 Milk™ decreased the severity of some lactose malabsorptive symptoms in lactose intolerant subjects. Furthermore, self-reported dairy intolerance without lactose malabsorption is identified in those with rapid, transient symptoms after milk ingestion, irregardless of lactose or β-casein content. American Journal of Clinical Nutrition 10.1093/ajcn/nqz279
2019 Shrestha A, Prodhan UK, Mitchell SM, Sharma P, Barnett MPG, Milan AM, Cameron-Smith D. Validity of a portable breath analyser (AIRE) for the assessment of lactose malabsorption. A portable breath analyser is successfully validated against a calibrated breath hydrogen analyser in participants experiencing lactose malabsorption. Nutrients 10.3390/nu11071636




Infant Health




Title Summary Published DOI
2019 McKeen S, Young W, Mullaney J, Fraser K, McNabb W, and Roy N. Infant Complementary Feeding of Prebiotics for the Microbiome and Immunity A review of introducing complex, non-digestable carbohydrates to infants during the stage of complementary feeding, which promotes intestinal barrier integrity and immune development. Nutrients 10.3390/nu11020364
2018 Michelini S, Balakrishnan B, Parolo S, Matone A, Mullaney J, Young W, Gasser O, Wall C, Priami C, Lombardo R, Kussmann M. A reverse metabolic approach to weaning: in silico identification of immune-beneficial infant gut bacteria, mining their metabolism for prebiotic feeds and sourcing these feeds in the natural product space Identification of an optimal weaning food for infant gut bacteria proliferation is determined by identifying the metabolite requirements of beneficial gut bacteria, determining the nutrients that contain these metabolites and, in turn, uncovering a potential ‘first food’ to boost the immune system of infants in the critical stage of complementary feeding. Microbiome 10.1186/s40168-018-0545-x